This project will aim to develop integrated approaches and tools to more accurately predict clinical prognosis and outcomes in patients with DCM, enabling improved clinical intervention to reduce mobidity and mortality. By gaining a more comprehensive knowledge of the genetic architecture of DCM, it will also enable more effective and precise clinical genetic testing and enhanced risk prediction for relatives who carry the primary disease-causing genetic variant within families, allowing more tailored clinical monitoring and intervention.
By gaining a more comprehensive understanding of the aetiology and disease mechanisms underlying DCM (through genomics, transcriptomics and animal models), the project will also aim to identify novel and potentially impactful targets for new therapeutic approaches and address the major unmet medical need for this condition.