The papers listed below are some of the key recent studies and guidelines documents from DCM-NEXT consortium members relating to research on DCM and related cardiomyopathies.
2023
Arbelo et al, 2023 ESC Guidelines for the management of cardiomyopathies: Developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC). European Heart Journal 2023
Lipov et al, Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies. Nature Cardiovascular Research 2023.
Verdonschot et al, Clustering of Cardiac Transcriptome Profiles Reveals Unique: Subgroups of Dilated Cardiomyopathy Patients. JACC Basic Transl Sci. 2023
2022
Reichart et al, Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science 2022
Mirelis et al, Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non-ischaemic dilated cardiomyopathy. Eur J Heart Fail 2022
Zeppenfeld et al, 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2022
Tayal et al, Precision Phenotyping of Dilated Cardiomyopathy Using Multidimensional Data. J Am Coll Cardiol 2022
2021
Tadros et al, Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nat Genet 2021
Larrasa-Alonso et al, The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy. Circulation Research 2021
Escobar-Lopez et al, Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy. J Am Coll Cardiol 2021
Verdonschot et al, Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences. Eur Heart J 2021
Garnier et al, Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. Eur Heart J 2021
Tadros et al, Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nat. Genetic 2021
2020
Mazzarotto et al, Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy. Circulation 2020
Schmidt et al, Genetic drug target validation using Mendelian randomization. Nat Commun 2020
Litviňuková et al, Cells of the adult human heart. Nature 2020
Sánchez-Cabo et al, Machine Learning Improves Cardiovascular Risk Definition for Young, Asymptomatic Individuals. J Am Coll Cardiol 2020
Verdonschot et al, Distinct Cardiac Transcriptomic Clustering in Titin and Lamin A/C-Associated Dilated Cardiomyopathy Patients. Circulation 2020
Meyer at al, Genetic and functional insights into the fractal structure of the heart. Nature 2020
2019
van Heesch et al, The Translational Landscape of the Human Heart. Cell 2019
Padrón-Barthe et al, Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β. Circulation 2019
Garcia Pavia et al, Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy. Circulation 2019
2018
Charron et al, The Cardiomyopathy Registry of the EURObservational Research Programme of the European Society of Cardiology: baseline data and contemporary management of adult patients with cardiomyopathies. Eur Heart J 2018