The papers listed below are some of the key recent studies and guidelines documents from DCM-NEXT consortium members relating to research on DCM and related cardiomyopathies.
2024
Ochoa et al, Biallelic Loss of Function Variants in Myocardial Zonula Adherens Protein Gene (MYZAP) Cause a Severe Recessive Form of Dilated Cardiomyopathy. Circulation: Heart Failure 2024.
Lukas et al, Causal inference in the field of arrhythmia: An introduction to mendelian randomization. Heart Rhythm 2024.
Sikking et al, Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy. Circulation Research 2024.
Jurgens et al, Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. Nature Genetics 2024.
van Vugt et al, Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation. Genome Medicine 2024.
Verdonschot et al, The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy. European Heart Journal 2024.
Bezzina et al, Top stories on genome-wide association studies. Heart Rhythm 2024.
2023
Schmidt et al, Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity. Science Advance 2023.
Arbelo et al, 2023 ESC Guidelines for the management of cardiomyopathies: Developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC). European Heart Journal 2023
Lipov et al, Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies. Nature Cardiovascular Research 2023.
Verdonschot et al, Clustering of Cardiac Transcriptome Profiles Reveals Unique: Subgroups of Dilated Cardiomyopathy Patients. JACC Basic Transl Sci. 2023.
2022
Reichart et al, Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science 2022.
Mirelis et al, Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non-ischaemic dilated cardiomyopathy. Eur J Heart Fail 2022.
Zeppenfeld et al, 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC) Endorsed by the Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2022.
Tayal et al, Precision Phenotyping of Dilated Cardiomyopathy Using Multidimensional Data. J Am Coll Cardiol 2022.
2021
Tadros et al, Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nat Genet 2021.
Larrasa-Alonso et al, The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy. Circulation Research 2021.
Escobar-Lopez et al, Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy. J Am Coll Cardiol 2021.
Verdonschot et al, Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences. Eur Heart J 2021.
Garnier et al, Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. Eur Heart J 2021.
Tadros et al, Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nat. Genetic 2021.
2020
Mazzarotto et al, Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy. Circulation 2020.
Schmidt et al, Genetic drug target validation using Mendelian randomization. Nat Commun 2020.
Litviňuková et al, Cells of the adult human heart. Nature 2020
Sánchez-Cabo et al, Machine Learning Improves Cardiovascular Risk Definition for Young, Asymptomatic Individuals. J Am Coll Cardiol 2020.
Verdonschot et al, Distinct Cardiac Transcriptomic Clustering in Titin and Lamin A/C-Associated Dilated Cardiomyopathy Patients. Circulation 2020.
Meyer at al, Genetic and functional insights into the fractal structure of the heart. Nature 2020.
2019
van Heesch et al, The Translational Landscape of the Human Heart. Cell 2019
Padrón-Barthe et al, Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β. Circulation 2019.
Garcia Pavia et al, Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy. Circulation 2019.
2018
Charron et al, The Cardiomyopathy Registry of the EURObservational Research Programme of the European Society of Cardiology: baseline data and contemporary management of adult patients with cardiomyopathies. Eur Heart J 2018.